Periodontitis, Experimental Gingivitis, Peri-implantitis
2023
Kerns, K.A., Bamashmous, S., Hendrickson, E.L., Kotsakis, G.A., Leroux, B.G., Daubert, D.D., Roberts, F.A., Chen, D., Trivedi, H.M., Darveau, R.P. & McLean, J.S. Localized microbially induced inflammation influences distant healthy tissues in the human oral cavity. Proceedings of the National Academy of Sciences 120: e2306020120, 2023
Fine, N., Barbour, A., Kaura, K., Kerns, K.A., Chen, D., Trivedi, H.M., Gomez, J., Sabharwal, A., McLean, J.S., Darveau, R.P. & Glogauer, M. Effects of a stabilized stannous fluoride dentifrice on clinical, immunomodulatory, and microbial outcomes in a human experimental gingivitis model. https://www.ncbi.nlm.nih.gov/pubmed/37885337J Periodontol , 2023
Baker, J.L., Mark Welch, J.L., Kauffman, K.M., McLean, J.S. & He, X. The oral microbiome: diversity, biogeography and human health. https://doi.org/10.1038/s41579-023-00963-6 Nature Reviews Microbiology, 2023
2021
Bamashmous, S., Kotsakis, G. A., Kerns, K. A., Leroux, B. G., Zenobia, C., Chen, D., Trivedi, H. M., McLean, J. S., & Darveau, R. P. (2021). Human variation in gingival inflammation. Proceedings of the National Academy of Sciences of the United States of America, 118(27), e2012578118.https://doi.org/10.1073/pnas.2012578118
Raw read and sample meta data are available on NCBI SRA, https://www.ncbi.nlm.nih.gov/sra (BioProject PRJNA615201) Data workflows and R code publicly available on GitHub (https://github.com/mcleanlab/HVGI_Study) and contains all necessary raw and processed files, (i.e., .biom, metadata.txt, .tree).
S Bamashmous, G Kotsakis, S Jain, AM Chang, JS Mclean, RP Darveau. Clinically healthy human gingival tissues show significant inter-individual variability in GCF chemokine expression and sub-gingival plaque microbial composition. Frontiers in Oral Health 2021 2, 37. https://doi.org/10.3389/froh.2021.689475
2020
Jonathan Y An, Kristopher A Kerns, Andrew Ouellette, Laura Robinson, H Douglas Morris, Catherine Kaczorowski, So-Il Park, Title Mekvanich, Alex Kang, Jeffrey S McLean, Timothy C Cox, Matt Kaeberlein. Rapamycin rejuvenates oral health in aging mice. eLife, 2020; 9 DOI: 10.7554/eLife.54318 BioProject Accession No: PRJEB35672
2019
Jain, S., Chang, A.M., Singh, M., McLean, J.S., Coats, S.R., Kramer, R.W. & Darveau, R.P. Identification of PGN_1123 as the gene encoding lipid A deacylase, an enzyme required for Toll-like receptor 4 evasion, in Porphyromonas gingivalis. J Bacteriol (2019). 2019 Feb 19. pii: JB.00683-18. doi: 10.1128/JB.00683-18. GEO Accession No : GSE122289
Chang AM, Liu Q, Hajjar AM, Greer A, McLean JS, Darveau.Toll-like receptor-2 and -4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota. J Periodontol. 2019 Oct;90(10):1202-1212. doi: 10.1002/JPER.18-0719. Epub 2019 Jul 1. PubMed PMID: 31111967; PubMed Central PMCID: PMC6791728
Coats SR, Kantrong N, To TT, Jain S, Genco CA, McLean JS, Darveau RP. The distinct immune-stimulatory capacities of Porphyromonas gingivalis strains 381 and ATCC 33277 are determined by the fimB allele and gingipain activity. Infect Immun. 2019 Sep 30;. doi: 10.1128/IAI.00319-19. [Epub ahead of print] PubMed PMID: 31570556. GEO Accession No : GSE128899
2018
Torres PJ, Thompson J, McLean JS, Kelley ST, Edlund A. Discovery of a Novel Periodontal Disease-Associated Bacterium. Microb Ecol. 2018 Jun 2. doi: 10.1007/s00248-018-1200-6. [Epub ahead of print] PubMed PMID: 29860637. BioProject Accession No : PRJNA289925
2017
Daubert D, Pozhitkov A, McLean J, Kotsakis G. Titanium as a modifier of the peri-implant microbiome structure. Clin Implant Dent Relat Res. 2018;1–9. https://doi.org/10.1111/cid.12676
2006-2016
To TT, Liu Q, Watling M, Darveau RP, Bumgarner RE, McLean JS*. (2016) Genome sequence of low-passage clinical isolate Porphyromonas gingivalis MP4-504. Genome Announcements In press.
GenBank Accession No : LOEL00000000
McLean, J. S.*, Q. Liu, J. Thompson, A. Edlund and S. Kelley (2015). "Draft Genome Sequence of "Candidatus Bacteroides periocalifornicus," a New Member of the Bacteriodetes Phylum Found within the Oral Microbiome of Periodontitis Patients." Genome Announc 3(6)
GenBank Accession No : LLVT00000000
McLean, JS.* and R. Lasken (2014). “Single cell genomics of bacterial pathogens:outlook for infectious disease research.” Genome Medicine 6(11): 108.
McLean, JS*, M.-J. Lombardo, M. G. Ziegler, M. Novotny, J. Yee-Greenbaum, J. H. Badger, G. Tesler, S. Nurk, V. Lesin, D. Brami, A. P. Hall, A. Edlund, L. Z. Allen, S. Durkin, S. Reed, F. Torriani, K. H. Nealson, P. A. Pevzner, R. Friedman, J. C. Venter and R. S. Lasken (2013). “Genome of the pathogen Porphyromonas gingivalis recovered from a biofilm in a hospital sink using a high-throughput single-cell genomics platform.” Genome Research 23(5): 867-877. doi: 10.1101/gr.150433. PMCID: PMC3638142 http://genome.cshlp.org/content/23/5/867.long
BioProject Accession No : PRJNA167667